Author: Rick Maizels
New Paper on TGM Engineering: a new inhibitor of fibroblast TGF-β signalling
Cunningham, K.T., Ciancia, C., Campion, T., van Dinther, M., Davis, N. Duffy, A., Power, L., Sanders, A., Singh, S.P., Smyth, D.J., Thompson, E., White, R., Hinck, A.P., ten Dijke, P. and Maizels, R.M. (2026) Molecular engineering of the helminth TGFβ mimetics, […]
Read moreNew Paper on TGM2
Emma Ntang’s paper on TGM2 has been published in Genes and Immunity! Ntang, E.Y., Cunningham, K.T., Singh, S.P., Ciancia, C., Sanders, A., Lilla, S., Mukundan, A., Ghogomu, S.M., Hinck, A.P. and Maizels, R.M. (2025). Structural and functional analysis of the […]
Read moreNew interview in Freethink
Namir Khaliq, journalist with Freethink, has published a commentary including an interview with Rick Maizels
Read moreTwo new papers from the Maizels Lab
Just published ! A major review on TGF-β mimics and Cytokines from Parasites : Maizels RM, McSorley HJ, Smits HH, ten Dijke P, Hinck AP (2025) Cytokines from parasites: Manipulating host responses by molecular mimicry. Biochem J 482: 1-18. PDF […]
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New Paper on TGM6, TGF-β Antagonist, in Nature Communications
Exciting new paper led by Andy Hinck’s lab on TGM6 is now available online Doi is https://doi.org/10.1038/s41467-025-56954-z.
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New Collaborative Project starts in Rick Maizels’ Lab
An exciting new collaborative project, funded by a Wellcome Discovery Award, is starting in Rick Maizels’ lab, together with leading figures in the area of helminth immunology (Henry McSorley, University of Dundee and Hermelijn Smith, Leiden University Medical Center) and […]
Read moreNew Paper on TGM4 in EMBO Reports – Singh et al. (2025)
We are excited to see our new paper, first authored by Shashi Singh, on how TGM4 has preference for myeloid cell activation through an extended set of co-receptors: download the PDF here ! Singh, S.P., Smyth, D.J., Cunningham, K.T., Mukundan, […]
Read moreNew Paper on Tuft Cell Acetylcholine in Immunity
Our collaboration with Philippe Jay at INSERM in Montpellier has continued with a new publication in Immunity, Tuft cell acetylcholine is released into the gut lumen to promote anti-helminth immunity, by Marième Ndjim et al – click here for link to […]
Read moreCD44 coreceptor for TGM1 – published in PNAS
August 2023 : Exciting new data showing that TGM1 (H. polygyrus Transforming Growth factor-beta Mimic-1) binds not only the mammalian TGFβ receptors (as shown by Mukundan et al, 2022, doi 10.1016/j.jbc.2022.101994), but also CD44, enhancing potency for induction of regulatory T […]
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