Maizels Lab Publications 1991-2000 (66-147)


66.    Bradley, J.E., Helm, R., Lahaise, M. and Maizels, R.M.  (1991)  cDNA clones of Onchocerca volvulus low molecular weight antigens provide immunologically specific diagnostic probes.   Molecular and Biochemical Parasitology  46 : 219-228

67.    Day,K.P., Gregory,W.F. and  Maizels, R.M.  (1991)  Age-specific acquisition of immunity to infective larvae in a Bancroftian filariasis endemic area of Papua New Guinea.   Parasite Immunology  13 : 277-290

68.    Healer, J., Ashall, F. and Maizels, R.M.  (1991)  Characterization of proteolytic enzymes from larval and adult Nippostrongylus brasiliensis.  Parasitology  103 : 305-314.

69.    Khoo, K.-H., Maizels, R.M., Page, A.P., Taylor, G.W., Rendell, N.B. & Dell, A.  (1991)  Characterisation of nematode glycoproteins: the major O-glycans of Toxocara excretory-secretory antigens are O-methylated trisaccharides.  Glycobiology  1 : 163-171.

70.    Maizels, R.M. and Lawrence, R.A.  (1991)  Immunological tolerance: the key feature of human filariasis.  Parasitology Today  7: 271-276.

71.    Maizels, R.M. and Robertson, B.D.  (1991) Toxocara canis: Secreted glycoconjugate antigens in immunobiology and immunodiagnosis.  In Parasitic Nematodes - Antigens, Membranes and Genes  (Ed. Kennedy, M.) Taylor and Francis Ltd, London, pp 95-115

72.    Maizels, R.M., Blaxter, M.L., Robertson, B.D. and Selkirk, M.E. (1991)  Parasite Antigens, Parasite Genes.  A Laboratory Manual for  Molecular Parasitology.  Cambridge University Press, 224 pp. 

73.    Maizels, R.M., Kurniawan, A., Selkirk, M.E. and Yazdanbakhsh, M.  (1991)  Immune responses to filarial parasites.  Immunology Letters  30 : 249-254.

74.    Page, A.P., Richards, D., Lewis, J., Hussain, O. and Maizels, R.M.  (1991)  Comparison of isolates and species of  Toxocara and Toxascaris by biosynthetic labelling of somatic and ES proteins from infective larvae.    Parasitology 103 : 451-464.


75.    Adebajo, A.O., Akinsola, A., Maizels, R.M., Cawston, T.E. and Hazleman, B.L. (1992) Rheumatoid factor and rheumatoid factor isotypes on filariasis with and without accompanying glomerulo-nephritis.  Transactions of the Royal Society for Tropical Medicine and Hygiene 86 : 667-669.

76.    Blaxter, M.L., Page, A.P., Rudin, W. and Maizels, R.M.  (1992)  Nematode surface coats: actively evading immunity.  Parasitology Today  8 :  243-247

77.    Haswell-Elkins, M., Leonard, H., Kennedy, M., Elkins, D.B. and Maizels, R.M.  (1992)  Immuno-epidemiology of Ascaris lumbricoides :  Relationships between antibody specificities, exposure and infection  in a human community.   Parasitology  104: 153-159.

78.    Maizels, R.M. and Denham, D.A. (1992) Diethylcarbamazine (DEC): immunopharma-cological interactions of an anti-filarial drug.  Parasitology 105 (Suppl.): S49-S60.

79.    Maizels, R.M. and Partono, F.  (1992)  Lymphatic filariasis.  Medicine International, 4548-4551

80.    Page, A.P. and Maizels, R.M.  (1992) Biosynthesis and glycosylation of serine/threonine-rich secreted proteins from Toxocara canis larvae.  Parasitology 105 : 297-308 

81.    Page, A.P., Hamilton, A.J  and Maizels, R.M. (1992)  Toxocara canis : monoclonal antibodies to carbohydrate epitopes of  secreted (TES) antigens  localize to different secretion-related structures in infective larvae.  Experimental Parasitology  75 : 56-71

82.    Page, A.P., Rudin, W. and Maizels, R.M. (1992)   Lectin binding to secretory structures, cuticle and surface coat of Toxocara canis infective larvae.  Parasitology 105 : 285-296

83.    Page, A.P., Rudin, W., Fluri, E., Blaxter, M.L.  and Maizels, R.M.  (1992)  Toxocara canis : a labile antigenic coat overlying the epicuticle of infective lavae.   Experimental Parasitology 75 : 72-86

84.    Selkirk, M.E., Maizels, R.M. and Yazdanbakhsh, M.  (1992)  Immunity and the prospects for vaccination against filariasis.  Immunobiology  184 : 263-281


85.    Bradley, J.E., Tuan, R.S., Shepley, K.J., Tree, T.I.M.,  Maizels, R.M., Helm, R., Gregory, W.F. and Unnasch, T.R. (1993)  Onchocerca volvulus : characterization of an immunodominant hypodermal antigen present in adult and larval parasites.  Experimental Parasitology 77: 414-424

86.    Gillespie, S.H., Bidwell, D., Voller, A., Robertson, B.D. and Maizels, R.M.  (1993)  Diagnosis of human toxocariasis by antigen capture enzyme linked immunosorbent assay.  Journal of Clinical Pathology 46: 551-554

87.    Kurniawan, A., Yazdanbakhsh, M., van Ree, R., Aalberse, R., Selkirk, M.E., Partono, F. and Maizels, R.M.   (1993)  Differential expression of IgE and IgG4 specific antibody responses in asymptomatic and chronic human filariasis.  Journal of Immunology 150 : 3941-3950

88.    Lewis, J. & Maizels, R.M., Eds.  (1993)  Toxocara and Toxocariasis: Clinical, Epidemiological and Molecular Perspectives.  Institute of Biology, London, 169 pp.

89.    Maizels, R.M., Blaxter, M.L. and Selkirk, M.E.  (1993)   Forms and functions of nematode surfaces.  Experimental Parasitology 77: 380-384

  90.    Maizels, R.M., Bundy, D.A.P., Selkirk, M.E., Smith, D.F. and Anderson, R.M.  (1993)  Immunological modulation and evasion by helminth parasites in human communities.  Nature 365: 797-805

91.    Maizels, R.M., Gems, D.H.  and Page, A.P.  (1993) Synthesis and secretion of Toxocara ES antigens.   In Toxocara and Toxocariasis: Clinical, Epidemiological and Molecular Perspectives (Lewis, J. & Maizels, R.M., Eds.) Institute of Biology, London, pp 141-150

92.    Paxton, W.A., Yazdanbakhsh, M., Kurniawan, A., Partono, F., Maizels, R.M. and Selkirk, M.E.  (1993)  Primary structure of and Immunoglobulin E response to the repeat subunit of gp15/400 from human lymphatic filarial parasites.  Infection and Immunity  61: 2827-2833

93.    Rathaur, S., Müller, S., Maizels, R.M. and Walter, R.D.  (1993)  Identification of circulating parasite acetylcholinesterase in human and rodent filariasis.  Parasitological Research  78: 671-676 

94.    Selkirk, M.E., Gregory, W.F., Jenkins, R.E. & Maizels, R.M.  (1993)  Localisation, turnover and conservation of gp15/400 in different stages of Brugia malayi.  Parasitology 107: 449-457

95.    Tweedie, S.A.R., Paxton, W.A., Ingram, L., Maizels, R.M., McReynolds, L.A. and Selkirk, M.E.  (1993)  A surface-associated glycoprotein (gp15/400) from Brugia filarial parasites is composed of multiple tandemly-repeated units and processed from a 400 kDa precursor.  Experimental Parasitology 76: 156-164

96.    Yazdanbakhsh, M., Paxton, W. A., Kruize, Y. C. M., Sartono, E., Kurniawan, A., van het Wout, A., Selkirk, M. E., Partono, F. & Maizels, R. M. (1993). T cell responsiveness correlates with antibody isotype levels in clinical and asymptomatic lymphatic filariasis. Journal of Infectious Diseases 167: 925-931. 

97.    Yazdanbakhsh, M., Sartono, E., Kruize, Y., van der Pouw-Kraan, T., van der Meide, P.H., Selkirk, M.E., Hintzen, R.Q.,  van Lier, R.A.W.,  and Maizels, R.M.  (1993)  Elevated levels of T cell activation antigen CD27 and increased Interleukin-4 production in human lymphatic filariasis.  European Journal of Immunology 23 : 3312-3317


98.    Lawrence, R.A., Allen, J.E., Osborne, J. and Maizels, R.M.  (1994)  Adult and microfilarial stages of the filarial parasite Brugia malayi stimulate contrasting  cytokine and immunoglobulin isotype responses in BALB/c mice.  Journal of Immunology 153 : 1216-1224

99.    Trenholme, K.R., Tree, T.I.M., Gillespie, A.J., Guderian, R., Maizels, R.M. and Bradley, J.E.  (1994) Heterogeneity of IgG antibody responses to cloned Onchocerca volvulus antigens in microfilardermia positive individuals from Esmeraldas Province, Ecuador.   Parasite  Immunology 16 : 201-209


100.  Allen, J.E., Lawrence, R.A. and Maizels, R.M.  (1995) Fine specificity of the genetically controlled immune response to native and recombinant gp15/400 (polyprotein allergen) of Brugia malayi.  Infection and  Immunity63: 2892-2898

101.  Maizels, R.M., Sartono, E., Kurniawan, A., Selkirk, M.E., Partono, F. and  Yazdanbakhsh, M. (1995) T cell activation and the balance of antibody isotypes in human lymphatic filariasis.  Parasitology Today 11: 50-56 

102.  Gems, D.H., Ferguson, C.J., Robertson, B.D., Page, A.P., Nievos, R., Blaxter, M.L. and Maizels, R.M.  (1995) An abundant, trans-spliced mRNA from Toxocara canis infective larvae encodes a 26 kDa antigen with homology to phosphatidylethanolamine-binding proteins.  Journal of Biological Chemistry  270: 18517-18522.

103.  Kurniawan, A., Atkinson, R., Sartono, E., Partono, F., Yazdanbakhsh, M. and Maizels, R.M.  (1995)  Differential decline in filarial-specific IgG1, IgG4 and IgE antibodies in Brugia malayi–infected patients following diethylcarbamazine chemotherapy.  Journal of Infectious Diseases 172: 1567-1572

104.  Lawrence, R.A., Allen, J.E., Gregory, W.F., Kopf, M.  and Maizels, R.M.   (1995)    Infection of IL-4 deficient mice with the parasitic nematode Brugia malayi demonstrates that host resistance is not dependent on a Th2 dominated immune response.   Journal of Immunology   154 : 5995-6001

105.  Sartono, E., Kruize, Y.C.M., Kurniawan, A., van der Meide, P.H., Partono, F., Maizels, R.M. and Yazdanbakhsh, M.  (1995)  Elevated cellular immune responses and IFN-g release after long-term DEC treatment of human lymphatic filariasis patients.  Journal of Infectious Diseases 171: 1683-1687

106.  Sartono, E., Kruize, Y.C.M., Partono, F., Kurniawan, A.,  Maizels, R.M. and Yazdanbakhsh, M.  (1995)  Specific T cell unresponsiveness in human filariasis: diversity in underlying mechanisms.  Parasite Immunology 17: 587-594

107.  Yazdanbakhsh, M., Sartono, E., Kruize, Y.C.M., Kurniawan, A., Partono, F., Maizels, R.M., Schreuder, G.M.T., D’amaro, J., Schippers, R. and de Vries, R.R.P. (1995)  HLA and elephantiasis in lymphatic filariasis.  Human Immunology  54: 58-61.

108.  Yazdanbakhsh, M., Paxton, W.A., Brandenburg, A., van Ree, R., Lens, M., Partono, F., Maizels, R.M. and Selkirk, M.E.  (1995)  Differential antibody isotype reactivity to specific antigens in human lymphatic filariasis : Gp15/400 preferentially induces IgE, IgG4 and IgG2.  Infection and Immunity 63 : 3772-3779


   109. Allen, J.E., Lawrence, R.A. and Maizels, R.M.  (1996)  Antigen presenting cells from mice harboring the filarial nematode, Brugia malayi, prevent cellular proliferation but not cytokine production.   International Immunology  8: 143-151

110.  Allen, J.E. and Maizels, R.M.  (1996) Immunology of helminth infections in humans.  International Archives of Allergy and Immunology 109  : 3-10

111.  Burkot, T.R., Kwan-Lim, G.-E. and Maizels, R.M.  (1996)  A novel 95-kilodalton antigen of Wuchereria bancrofti  infective larvae identified by species-specific monoclonal antibodies.  Infection and Immunity 64 : 485-488

   112. Gems, D.H. and Maizels, R.M.  (1996)  An abundantly expressed mucin-like protein from Toxocara canis infective larvae:  the precursor of the larval surface coat glycoproteins. Proceedings of the National Academy of Sciences 93: 1665-1670

113.  Holmes, B.J., Diaz-Sanchez, D., Lawrence, R.A., Bell, E.B., Maizels, R.M. and Kemeney, D.M. (1996) The contrasting effects of CD8+ cells on primary, established and Nippostrongylus brasiliensis-induced IgE responses.  Immunology 88: 252-260

114.  Lawrence, R.A., Gray, C., Osborne, J. and Maizels, R.M. (1996) Nippostrongylus brasiliensis: T helper subset responses and nematode expulsion in normal and IL4-deficient mice. Experimental Parasitology 84 : 65-73

115.  Murdoch, M.E., Abiose, A., Garate, T., Hay, R.J., Jones, B.R., Maizels, R.M. and Parkhouse, R.M.E. (1996)    Nigerian human onchocerciasis: IgG subclass antibody responses and antigen recognition in individuals with defined cutaneous pathology.  American Journal of Tropical  Medicine and Hygiene  54 : 600-612

116.  Sartono, E., Kruize, Y.C.M., Kurniawan, A., Maizels, R.M.  and Yazdanbakhsh, M. (1996) In Th2 biased lymphatic filarial patients, responses to PPD remain Th1.  European Journal of Immunology 26 : 501-504.

117.  Yazdanbakhsh, M., Sartono, E., Selkirk, M.E.  and Maizels, R.M.  (1996) T cell activation and antibody responses in lymphatic filariasis.  In T-Cell Subsets and Cytokines Interplay in Infectious Diseases (eds: Mustafa, A.S., Al-Attiya, R.J., Nath, I. & Chugh, T.D.)  S.Karger AG, Basel, pp 153-168


118.  Allen, J.E. and Maizels, R.M.  (1997) Th1 and Th2: reliable paradigm or dangerous dogma ? Immunology Today  18 : 387-392

119.  Gomez-Escobar, N., van den Biggelaar, A.  and Maizels, R.M.    (1997)   A member of the TGF-b receptor gene family in the parasitic nematode Brugia malayi.   Gene  199: 101-109

120.  Gregory, W.F., Blaxter, M.L.  and Maizels, R.M.    (1997) Differentially expressed, abundant trans-spliced cDNAs from larval Brugia malayi.  Molecular and Biochemical Parasitology 87: 85-95

121.  Murdoch, M.E., Payton, A., Abiose, A., Thomson, W., Panicker, V.K., Dyer, P., Jones, B.R., Maizels, R.M. and Ollier, W. (1997)  HLA-DQ alleles associate with cutaneous features of onchocerciasis.  Human Immunology 55: 46-52

122.  Sartono, E., Kruize, Y.C.M., Kurniawan-Atmadja, A., van der Meide, P.H.,  Maizels, R.M. and Yazdanbakhsh, M. (1997)  Depression of antigen-specific interleukin-5 and interferon-g responses in human lymphatic filariasis as a function of clinical status and age.   Journal of Infectious Diseases 175 : 1276-1280.

123.  Sartono, E., van Eggermond, M.C.J.A., Kurniawan, A., Maizels, R.M., van den Elsen, P.J.  and Yazdanbakhsh, M.  (1997) Selective usage of defined TCRBV genes in response to filarial antigens.  International Immunology 9: 955-962


124.  Gomez-Escobar, N., Lewis, E.  and Maizels, R.M.  (1998)  A novel member of the transforming growth factor-b(TGF-b) superfamily from the filarial nematodes Brugia malayi and B. pahangi.  Experimental Parasitology 88: 200-209

125.  Kurniawan, A., Sartono, E., Partono, F., Yazdanbakhsh, M. and Maizels, R.M.  (1998)  Antibody responses to filarial infective larvae are not dominated by the IgG4 isotype. Parasite Immunology  20: 9-17

126.  Kurniawan, A., Sartono, E., Partono, F., Yazdanbakhsh, M. and Maizels, R.M.  (1998)  Specificity of predominant IgG4 antibodies to adult and microfilarial stages of Brugia malayi.  Parasite Immunology  20: 155-162

127.  Loukas, A.C. and Maizels, R.M.  (1998)  Cloning and characterization of a prohibitin gene from infective larvae of the parasitic nematode  Toxocara canisDNA Sequence  67: 1-6.

128.  Loukas, A.C., Selzer, P.M. and Maizels, R.M.  (1998)  Characterisation of Tc-cpl-1, a cathepsin L-like cysteine proteinase from Toxocara canis infective larvae. Molecular and Biochemical Parasitology  92: 275-289

129.  MacDonald, A.S.,  Maizels, R.M., Lawrence, R.A., Dransfield, I.  and Allen, J.E. (1998) Requirement for in vivo production of IL-4, but not IL-10, in the induction of proliferative suppression by filarial parasites. Journal of Immunology 160 : 1304-1312

130.  Maizels, R.M. and Holland, M.J.  (1998)  Parasite immunity: pathways for expelling intestinal helminths.  Current Biology  8 : R711-R714


131.  Loukas, A., Hunt, P. and Maizels, R.M.  (1999)  Cloning and expression of an aquaporin-like gene from a parasitic nematode.   Molecular and Biochemical Parasitology  99: 287-293

   132. Loukas, A., Mullin, N.P., Tetteh, K.K.A., Moens, L. and Maizels, R.M.  (1999)  A novel member of the C-type lectin gene family encodes the major secretory product of a tissue-dwelling parasitic nematode.  Current Biology  9 : 825-828

133.  Maizels, R.M., Holland, M., Falcone, F., Zang, X.X. and Yazdanbakhsh, M.  (1999) Vaccination against helminth parasites : the ultimate challenge for immunologists?   Immunological Reviews  171 :125-148

134.  Sartono, E., Lopriore, C., Kruize, Y.C.M., Kurniawan-Atmadja, A., Maizels, R.M. and Yazdanbakhsh, M.  (1999) Reversal in microfilarial density and T cell responses in human lymphatic filariasis. Parasite Immunology  21: 565-571

135.  Tetteh, K.K.A., Loukas, A., Tripp, C.  and Maizels, R.M.   (1999) Identification of abundantly-expressed, novel and conserved genes from the infective larval stage of Toxocara canis by an EST strategy.   Infection and Immunity  67: 4771-4779

136.  Zang, X.X., Yazdanbakhsh, M., Kiang, H., Kanost, M.R. and Maizels, R.M. (1999)  A novel serpin expressed by the blood-borne microfilariae of the parasitic nematode Brugia malayi  inhibits human neutrophil serine proteinases.   Blood 94 : 1418-1428


137.  Falcone, F., Tetteh, K.K.A., Hunt, P., Blaxter, M.L. Loukas, A. and Maizels, R.M.  (2000)  The new subfamily of cathepsin Z-like protease genes includes Tc-cpz-1, a cysteine protease gene expressed in Toxocara canisadults and infective stage larvae.  Experimental Parasitology 94: 201-207

   138. Gomez-Escobar, N., Gregory, W.F. and Maizels, R.M.  (2000)  Identification of Bm-tgh-2, a filarial nematode homolog  of C.elegans daf-7 and human TGF-b, expressed in  microfilarial and adult stages of Brugia malayi.  Infection and Immunity 68 : 6402-6410

   139. Gregory, W.F., Atmadja, A.K., Allen, J.E. and Maizels, R.M.  (2000) The abundant larval transcript-1 and -2genes of Brugia malayi encode stage-specific candidate vaccine antigens for filariasis.  Infection and Immunity68: 4174-4179

140.  Holland, M.J., Harcus, Y.M., Riches, P.L. and Maizels, R.M. (2000) Proteins secreted by the parasitic nematode Nippostrongylus brasiliensis act as adjuvants for Th2 responses.  European Journal of Immunology 30: 1977-1987

141.  Loke, P., MacDonald, A.S., Robb, A., Maizels, R.M. and Allen, J.E. (2000) Alternatively activated macrophages induced by nematode infection inhibit proliferation via cell to cell contact.   European Journal of Immunology 30: 2669-2678

142.  Loukas, A. and Maizels, R.M.  (2000) Helminth C-type lectins and host-parasite interactions.  Parasitology Today  16 : 333-339

143.  Loukas, A.,  Doedens, A., Hintz, M. and Maizels, R.M.  (2000) Identification of a new C-type lectin, TES-70, secreted by infective larvae of Toxocara canis, which binds to host endothelial cells.  Parasitology 121: 545-554

144.  Loukas, A.C., Hintz, M., Linder, D., Mullin, N.P., Parkinson, J., Tetteh, K.K.A. and Maizels R.M.  (2000)  A family of secreted mucins from the parasitic nematode Toxocara canis bear diverse mucin domains but share similar flanking six-cysteine (SXC) repeat motifs.  Journal of Biological Chemistry 275 : 39600-39607

145.  Maizels, R.M., Allen, J.E. and Yazdanbakhsh, M. (2000)  Immunology of Lymphatic Filariasis : Current Controversies. In Lymphatic Filariasis (ed. Nutman T.B.), Imperial College Press, pp 217-243

146. Maizels, R.M., Tetteh, K.K.A. and Loukas, A. (2000) Toxocara canis : Genes expressed by the arrested infective larval stage of a parasitic nematode.  International Journal of Parasitology 30: 495-508

147.  Zang, X.X.,  Kurniawan, A.K., Gray, P., Allen, J.E., Gray, C., Lawrence, R.A., Yazdanbakhsh, M. and Maizels, R.M.  (2000)  The serpin secreted by Brugia malayi microfilariae, Bm-SPN-2, elicits strong but short-lived immune responses in mice and humans.  Journal of Immunology 165: 5161-5169