Maizels Lab Publications 2001-2010 (148-226)


148.  Doedens, A., Loukas, A.C. and Maizels R.M.  (2001)  MUC-5 : a new mucin gene from Toxocara canis.   Acta Tropica 79 : 211-217

149.  Falcone, F. H., Loke, P., Zang, X., MacDonald, A. S., Maizels, R. M. & Allen, J. E. (2001). A Brugia malayihomolog of macrophage migration inhibitory factor reveals an important link between macrophages and eosinophil recruitment during nematode infection. Journal of Immunology   167, 5348-5354

150. Falcone, F., Rossi, A., Sharkey, R., Brown, A.P., Pritchard, D.I. and Maizels, R.M. (2001) Ascaris suum derived products induce neutrophil activation via a putative novel G-protein coupled receptor that interacts with the IL-8 receptor pathway.   Infection and Immunity 69 : 4007-4018

151.  Maizels, R.M., Blaxter, M.L. and Scott, A.L. (2001) Immunogenomics of filariasis: genes and gene families implicated in immune evasion and protective immunity.  Parasite Immunology  23: 327-344

152. Maizels, R. M., Gomez, N., Gregory, W.F., Murray, J., and Zang, X.X. (2001). Immune evasion genes from filarial nematodes.  International Journal of Parasitology  31: 889-898.

153. Maizels, R.M.  and Loukas, A. (2001)  The surface and secreted antigens of Toxocara canis: genes, protein structure and function. In Parasitic Nematodes - Molecular Biology, Biochemistry and Immunology, Eds  M. W. Kennedy and W. Harnett, (ISBN 0 85199 423 7) pp 229-246

154.  Manoury, B., Gregory, W.F., Maizels, R.M. and Watts, C.  (2001)  CPI-2, a cystatin homologue secreted by the filarial parasite Brugia malayi inhibits class II MHC-restricted antigen processing.  Current Biology, 11: 447-451

155.  Murray, J., Gregory, W. F., Gomez-Escobar, N., Atmadja, A. K. & Maizels, R. M. (2001). Expression and immune recognition of Brugia malayi VAL-1, a homologue of vespid venom allergens and Ancylostoma secreted proteins. Molecular and Biochemical Parasitology   118, 89 – 96

156.  Terhell, A.J., Haarbrink, M., Abadi, K., Syafruddin, Maizels, R.M., Yazdanbakhsh, M. and Sartono, E. (2001) Adults acquire filarial infection more rapidly than children: a study in Indonesian transmigrants.  Parasitology122: 633-640 

157.  Yazdanbakhsh, M., van den Biggelaar, A. and Maizels, R.M.  (2001) Th2 responses without atopy: immunoregulation in chronic helminth infections and reduced allergic disease.   Trends in Immunology  22 : 372-377

158.  Zang, X. and Maizels, R.M. (2001)  Serine proteinase inhibitors from nematodes and the arms race between host and pathogen.  Trends in Biochemical Sciences 26: 191-197


   159. Fernandez, C., Gregory, W.F., Loke, P., and Maizels, R.M.  (2002)  Full-length-enriched cDNA libraries from Echinococcus granulosus contain separate populations of oligo-capped and trans-spliced transcripts and a high level of predicted signal peptide sequences.   Molecular and Biochemical Parasitology 122: 171-180

160. LoVerde, P.T., Li, C.,  Maizels, R.M., Geary, T.G. and Colley, D.G.  (2002) Molecular helminthology: an integrated approach. American Journal of Tropical Medicine and Hygiene  66: 346-347

161.  Maizels, R..M. and Atmadja, A.K. (2002) Variation and polymorphism in helminth parasites. Parasitology 125: S25-S37

   162. Zang, X., Taylor, P., Meyer, D.J., Wang, J.M.,  Scott, A.L., Walkinshaw, M.D. and Maizels, R.M. (2002) Homologues of human macrophage migration inhibitory factor from a parasitic nematode: Gene cloning, protein activity and crystal structure.  Journal of Biological Chemistry 277 : 44261-44267

163.  Gomez-Escobar, N., Gregory, W.F., Britton, C., Murray, L., Corton, C., Hall, N., Daub, J., Blaxter, M.L. and Maizels, R.M. (2002)   Abundant Larval Transcript (alt-1 and -2 genes from Brugia malayi : diversity of genomic environments  but conservation of 5' promoter sequences functional in Caenorhabditis elegans.   Molecular and Biochemical Parasitology 125: 59-71


164.  Maizels, R. M. and Yazdanbakhsh, M. (2003) Immune regulation by helminth parasites - cellular and molecular mechanisms. Nature Reviews Immunol 3: 733-744

165.  Maizels, R. M. and Selkirk, M.E. (2003) Editors: Molecular and Cellular Biology of Helminth Parasites. International Journal of Parasitology 33: 1127-1302

166.  Noordin, R., Shenoy, R.K., Nutman, T.B., Weiss, N. Gilmour, K., Maizels, R.M., Yazdanbakhsh, M. and Sartono, E. (2003)  Multicenter laboratory evaluation of Brugia Rapid dipstick test for detection of Brugian filariasis. Tropical Medicine and International Health 10 : 895-900. 


167.  Balic, A., Harcus, Y., Holland, M.J., and Maizels, R.M. (2004) Selective maturation of dendritic cells by Nippostrongylus brasiliensis secreted proteins drives T helper type 2 immune responses. European Journal of Immunology 34: 3047-3059

168.  Fischer, P. Supali, T. and Maizels, R.M. (2004) Lymphatic filariasis due to Brugia timori and its prospects for elimination. Trends in Parasitology20: 351-355. 

169. Freire, T.,  Fernández, C., Chalar, C., Maizels, R.M., Alzari, P., Osinaga, E. and Robello, C. (2004) Characterization of a UDP-N-acetyl-D-galactosamine: poly- peptide N-acetyl-galactosaminyl-transferase with an unusual lectin domain from the platyhelminth parasite Echinococcus granulosus. Biochemical Journal 382: 501-510

   170. Harcus, Y.M., Parkinson, J., Fernández, C., Daub, J., Selkirk, M.E., Blaxter, M.L. and Maizels, R.M. (2004) Signal sequence analysis of expressed sequence tags from the nematode Nippostrongylus brasiliensis and the evolution of secreted proteins in parasites. Genome Biology 5: R39.1-15

171.  Maizels, R.M. and Balic, A. (2004) Resistance to helminth infection: the case for IL-5-dependent mechanisms Journal of Infectious Diseases 190 : 427-429

172.  Maizels, R.M., Balic, A., Gomez-Escobar, N., Nair, M., Taylor, M. and Allen, J.E. (2004) Helminth parasites – masters of regulation. Immunological Reviews 201: 89-116 

173.  Salinas, G., Selkirk, M.E., Chalar, C., Maizels, R.M. and Fernández, C.  (2004) Linked thioredoxin-glutathione systems in Platyhelminths. Trends in Parasitology20:  340-346. 

174.  Wilson, M.S. and Maizels, R.M. (2004)  Regulation of allergy and autoimmunity in helminth infection. Clinical Reviews in Allergy and Immunology 26: 35-50


175.  Gomez-Escobar, N., Bennett, C., Prieto-Lafuente, L., Aebischer, T., Blackburn, C.C. and Maizels, R.M. (2005) Heterologous expression of the filarial nematode alt gene products reveals their potential to inhibit immune function.  BMC Biology 3: 8; 1-16

176.  Holland, M.J., Harcus, Y.M., Balic, A. and Maizels, R.M. (2005) Th2 induction by Nippostrongylus secreted antigens in mice deficient in B cells, eosinophils or MHC Class I-related ligands. Immunology Letters 96 : 93-101

177.  Maizels, R.M. (2005) Infections and allergy : helminths, hygiene and host immune regulation. Current Opinion in Immunology 17 : 656-661

178. Murray, J., Manoury, B., Balic, A., Watts, C. and Maizels, R.M.  (2005) Bm-CPI-2, a cystatin from Brugia malayinematode parasites, differs from C.elegans cystatins in a specific site mediating inhibition of the antigen-processing enzyme AEP. Molecular and Biochemical Parasitology 139 : 197-203

179.  Mutapi, F., Burchmore, R., Mduluza, T., Foucher, A., Harcus, Y., Nicoll, G., Midzi, N., Turner, C.M. and Maizels, R.M.  (2005) Praziquantel treatment of individuals exposed to Schistosoma haematobium enhances serological recognition of defined peptide antigens. Journal of Infectious Diseases 192 : 1108-1118

180.  Nair, M., Gallagher, I., Taylor, M., Loke, P., Coulson, P.S., Wilson, R.A., Maizels, R.M. and Allen, J.E. (2005).  Chitinase and FIZZ family members are a generalized feature of nematode infection with selective upregulation of Ym1 and Fizz1 by antigen-presenting cells. Infection and Immunity 73 : 385-394

181.  Noordin, R., Smith, H.V., Mohamed, S., Maizels, R.M. and Fong, M.Y.  (2005) Comparison of IgG-ELISA and IgG4-ELISA for Toxocara serodiagnosis. Acta Tropica 93: 57-62

182.  Pinelli, E., Withagen, C., Fonville, M., Verlaan, A., Dormans, J., van Loveren, H., Nicoll, G., Maizels, R.M. and van der Giessen, J. (2005) Persistent airway hyperresponsiveness and inflammation in Toxocara canis infected BALB/c mice. Clinical and Experimental Allergy 35: 826-832

  183.  Taylor, M.D., LeGoff, L., Harris, A., Malone, E., Allen, J.E. and Maizels, R.M. (2005) Removal of regulatory T cell activity reverses hyporesponsiveness and leads to filarial parasite clearance in vivoJournal of  Immunology 175 : 4924-4933

  184.  Wilson, M S., Taylor, M., Balic, A., Finney, C.A.M., Lamb, J.R. and Maizels, R.M. (2005)  Suppression of allergic airway inflammation by helminth-induced regulatory T cells. Journal of Experimental Medicine 202: 1199-1212.


185.  Balic, A., Harcus, Y., Taylor, M.D., Brombacher, F. and Maizels, R.M. (2006) IL-4R signaling is required to induce IL-10 for the establishment of Th2 dominance. International Immunology 18: 1421-1431

186.  Bulgheresi, S., Schabussova, I., Chen, T., Mullin, N.P., Maizels R.M. & Ott, J.A. (2006) A new C-type lectin similar to the human immunoreceptor DC-SIGN mediates symbiont acquisition by a marine nematode.  Applied and Environmental Microbiology 72: 2950-2956

187.  Maizels, R.M., Callister, D.M., Schabussova, I., and Nicoll, G. (2006) Molecular biology and immunology of Toxocara canis. In Toxocara the Enigmatic Parasite, (Eds,  Holland, C., and Smith, H.V.) CABI.  pp 3-17.

188.  Mutapi, F., Mduluza, T., Gomez-Escobar, N., Gregory, W.F., Fernandez, C., Midzi, N. and Maizels, R.M.  (2006) Immuno-epidemiology of Schistosoma haematobium infection: preferential IgG3 antibody responsiveness to a recombinant antigen dependent on age and parasite burden.   BMC Infectious Diseases 6: 96; 1-11

189.  Taylor, M.D., Harris, A., Nair, M.G., Maizels, R.M. and Allen, J.E. (2006) F4/80+ alternatively activated macrophages control CD4+ T cell hypo-responsiveness at sites peripheral to filarial infection. Journal of Immunology 176: 6918-6927

190.  Wilson, M.S. and Maizels, R.M. (2006) Regulatory T cells induced by parasites and the modulation of allergic responses. Parasites and Allergy, eds., Capron, M. and Trottein, F., Chemical Immunology and Allergy 90 : 176-195, S. Karger AG, Basel.


191.  Finney, C.A.M., Taylor, M.D., Wilson, M.S. and Maizels, R.M. (2007)  Expansion and activation of CD4+CD25+regulatory T cells in Heligmosomoides polygyrus infection.  European Journal of Immunology 37 : 1874-1886

192.  Maizels, R.M. (2007)  Regulation of the immune response in metazoan parasite infections.  Novartis Foundation Symposium 281  Decoding the Genomic Control of Immune Reactions.  pp 192-204, discussion 204-9  

193.  Mutapi, F., Winborn, G., Midzi, N, Taylor, M., Mduluza, T. and Maizels, R. M. (2007) Cytokine responses to Schistosoma haematobium in a Zimbabwean population: contrasting age profiles for IFN-γ, IL-4, IL-5 and IL-10 with age.  BMC Infectious Diseases 7: 139

194.  Schabussova, I., Amer, H.. van Die, I., Kosma, P and Maizels, R.M. (2007) O-methylated glycans from Toxocaraare specific targets for antibody binding in human and animal infections.  International Journal for Parasitology37: 97-109

  195.  Taylor, M.D., Harris, A., Babayan, S., Bain, O., Allen, J.E. and Maizels, R.M. (2007) CTLA-4 and CD4+CD25+regulatory T cells inhibit protective immunity to filarial parasites in vivo.  Journal of Immunology179 : 4626-4634


196.  Callister, D.M., Winter, A.W., Page, A.P. and Maizels, R.M. (2008) Homologous noncoding regions from four distinct  abundant novel transcript genes of Toxocara canis  are implicated in the control of gene expression. Molecular and Biochemical Parasitology 162 : 60-70

197.  Gregory, W.F. and Maizels, R.M.  (2008) Cystatins from filarial parasites: evolution, adaptation and function in the host-parasite relationship. International Journal of Biochemistry and Cell Biology40:1389–1398

  198.  Hewitson, J.P., Harcus, Y.M, Curwen, R.S., Dowle, A., Atmadja, A.K., Ashton, P., Wilson, A., and Maizels, R.M.  (2008)  The secretome of the filarial parasite, Brugia malayi: proteomic profile of adult excretory-secretory products.  Molecular and Biochemical Parasitology 160: 8-21

199.  MacDonald, A.S. and Maizels, R.M. (2008) Alarming dendritic cells for Th2 induction.  Journal of Experimental Medicine  205 : 13-17  

200.  McSorley, H., Harcus, Y., Murray, J., Taylor, M.D. and Maizels, R.M.  (2008) Expansion of Foxp3+ regulatory T cells in mice infected with the filarial parasite, Brugia malayi.  Journal of Immunology 181 : 6456-6466

201.  Maizels, R.M., Gomez-Escobar, N., Prieto-Lafuente, L., Murray, J. and Aebischer, T. (2008) Expression of helminth genes in Leishmania: an experimental transfection system to test immunological function.  Parasite Immunology 30:195-201

202.  Maizels, R.M. and Yazdanbakhsh, M. (2008) T cell regulation in helminth parasite infections : implications for inflammatory diseases. In T Cell Regulation in Allergy, Asthma and Atopic Skin Diseases (Ed. Blaser, K.; Karger Publishers, Basel, Switzerland) Chemical Immunology and Allergy94: 112-123 

203.  Mutapi, F., Burchmore, R.,  Mduluza, T.,  Midzi, N., Turner, C.M. & Maizels, R.M. (2008) Age- and intensity-related shifts in recognition of defined protein antigens in a Schistosome-exposed population.  Journal of Infectious Diseases 198: 167-175


204.  Balic, A., Smith, K.A., Harcus, Y. and Maizels, R. M. (2009) Dynamics of CD11c+ dendritic cell subsets  in lymph nodes draining the site of intestinal nematode infection. Immunology Letters 127: 68-75

205. Fernández, C. and Maizels, R.M. (2009) Generating EST libraries: trans-spliced cDNAs. Expressed Sequence Tags (ESTs): Generation and Analaysis (Ed Parkinson, J.) Humana Press, 24pp. Methods in Molecular Biology533:1-27

206.  González, S., Fló, M. Margenat, M., Durán, R., González-Sapienza, G., Graña, M., Parkinson, J., Maizels, R.M., Salinas, G.,  Álvarez, B. and Fernández, C. (2009).  A family of diverse Kunitz inhibitors from Echinococcus granulosus involved in host-parasite cross-talk in Echinococcosis.  PLOS One 4(9): e7009 (14pp) 

207.  Harcus, Y.M., Nicoll, G., Murray, J., Filbey, K., Gomez-Escobar, N., and Maizels, R.M. (2009)  C-type lectins from the nematode parasites Heligmosomoides polygyrus and Nippostrongylus brasiliensis. Parasitology International 58: 461-470

208.  Hewitson, J.P., Grainger, J.R. and Maizels, R.M. (2009) Helminth immunoregulation – the role of parasite secreted proteins in modulating host immunity. Molecular and Biochemical Parasitology 167 : 1-11

209.  Maizels, R.M. (2009) Exploring the immunology of parasitism: from surface antigens to the hygiene hypothesis. Parasitology136: 1549-1564

210.  Maizels, R.M.  (2009)  Parasite immunomodulation and polymorphisms of the immune system. Journal of Biology 8: 62 (4 pp)

211. Maizels, R.M., Pearce, E.J., Artis, D,  Yazdanbakhsh, M. and Wynn, T.A. (2009)  Regulation of pathology and immunity in helminth infections. Journal of Experimental Medicine  206: 2059-2066

212.  Maizels, R.M. and Weidermann, U. (2009) Immunoregulation by microbes and parasites in the control of allergy and autoimmunity.  In “The Hygiene Hypothesis and Darwinian Medicine” (Progress in Inflammation Research) ed. G.A.W. Rook, Birkhäuser Publishing, Basel, Switzerland,  pp 45-75

213.  Perona-Wright, G., Jenkins, S.J., O’Connor, R.A., Zienkiewicz, D., McSorley, H.J., Maizels, R.M., Anderton, S. M. and MacDonald, A.S.  (2009) A pivotal role for CD40-mediated IL-6 production by dendritic cells during IL-17 induction in vivo.  Journal of Immunology 182 : 2808-2815

214.  Prieto-Lafuente, L., Gregory, W.F., Allen, J.E. and Maizels, R.M. (2009) MIF homologues from a filarial nematode parasite synergize with IL-4 to induce alternative activation of host macrophages. Journal of Leucocyte Biology 85: 844-854

215.  Smith, H., Holland, C., Taylor, M., Magnaval, J.-F., Schantz, P. & Maizels, R.M. (2009) How common is human toxocariasis? Towards standardising our knowledge.  Trends in Parasitology 25: 182-188

216.  Sutherland, T., Maizels, R.M. and Allen, J.E.  (2009)  Chitinases and chitinase-like proteins: potential therapeutic targets for treatment of Th2 allergies. Clinical and Experimental Allergy 39 : 943-955

217.  Taylor, M.D., van der Werf, N., Harris, A., Graham, A.L., Bain, O., Allen, J.E. and Maizels, R.M. (2009) Early recruitment of natural CD4+Foxp3+ regulatory T cells by infective larvae determines the outcome of filarial infection.  European Journal of Immunology 39: 192-206


218.  Barnwell, E.M., van Deursen, F.J., Jeacock, L., Smith, K.A., Maizels, R.M., Alvaro Acosta-Serrano, A., and Matthews, K. (2010) Developmental regulation and extracellular release of a VSG expression site-associated gene product from Trypanosoma brucei bloodstream forms. Journal of Cell Science 123: 3401-3411

219.  Belkaid, Y., Liesenfield, O. and Maizels, R.M.  (2010)  Induction and control of regulatory T cells in the GI tract: consequences for local and peripheral immune responses. Clinical and Experimental Immunology 160:35-41

  220.  Grainger, J.R., Smith, K.A., Hewitson, J.P., McSorley, H.J., Harcus, Y., Filbey, K.J., Finney, C.A.M., Greenwood, E.J.D., Knox, D.P., Wilson, M.S., Belkaid, Y., Rudensky, A.Y., and Maizels, R.M. (2010) Helminth secretionsinduce de novo T cell Foxp3expression and regulatory function through the TGF-b pathway. Journal of Experimental Medicine 207: 2331-2341

221.  McSorley, H.J., Grainger, J.R., Harcus, Y.M., Murray, J.,  Nisbet, A., Knox, D. P. and Maizels, R.M. (2010)  daf-7-related TGF-b homologues from trichostrongyloid nematodes show contrasting life cycle expression patterns. Parasitology 137:159-171

222.  Milner, T., Reilly, L., Nausch, N., Midzi, N., Mduluza, T., Maizels, R.M. and Mutapi, F. (2010) Circulating cytokine and antibody levels in human Schistosoma haematobium: IL-5 and IL-10 levels depend on age and infection status. Parasite Immunology  32710-721

223.  Nisbet, A.J., Bell, N., McNeilly, T.N., Knox, D.P., Maizels, R.M., Meikle, L.I., Wildblood, L.A. and Matthews, J.B. (2010) A macrophage migration inhibitory factor-like tautomerase from Teladorsagia circumcincta (Nematoda: Strongylida). Parasite Immunolog7: 503-511

224.  Phythian-Adams, A.T., Cook, P.C., Lundie, R.J., Jones, L.H., Smith, K.A., Barr, T.A., Hochweller, K., Anderton, S.M., Hämmerling, G.J., Maizels, R.M. and MacDonald, A.S. (2010) CD11c depletion severely disrupts Th2 induction and development in vivo  Journal of Experimental Medicine 207: 2089-2096

225.  Wammes, L.J., Hamid, F., Wiria, A.E., de Gier, B., Sartono, E., Maizels, R.M., Luty, A.J., Fillié, Y.E., Brice, G.T., Supali, T., Smits, H.H. and Yazdanbakhsh, M.  (2010) Regulatory T cells in human geohelminth infection suppress immune responses to BCG and Plasmodium falciparum. European Journal of Immunology 40:437-442

226.  Wilson, M.S., Taylor, M.D., O’Gorman, M., Balic, A., Barr, T., Filbey, K., Anderton, S. and Maizels, R.M. (2010). Helminth-induced CD19+CD23hi B cells modulate experimental allergic and autoimmune inflammation. European Journal of Immunology40: 1682-1696