The following table is based on a summary of the immunomodulatory effects of H. polygyrus published in Maizels et al (2012) Experimental Parasitology 132:76-89 (PDF). Information up to the end of 2011 is included, check back for updates!
| Antigen-specific responses | |
| Antibody to SRBC inhibited in infection | (Ali and Behnke, 1983; Ali and Behnke, 1984; Shimp et al., 1975) |
| Antibody to SRBC inhibited by adult worm homogenate, and by cells from mice given adult worm homogenate | (Pritchard et al., 1984) |
| Antibody to ovalbumin | (Boitelle et al., 2005) |
| Immune cell functions | |
| Inhibition of DC responses to TLR ligation, and reduction of IL-12 secretion | (Massacand et al., 2009; Segura et al., 2007) |
| Expansion of Foxp3+ CD103+ Tregs | (Finney et al., 2007; Rausch et al., 2008) |
| Induction of bystander (OVA-specific) Foxp3+ Tregs | (Grainger et al., 2010) |
| Autoimmunity | |
| Inhibits colitis in IL-10-deficient mice | (Elliott et al., 2004; Hang et al., 2010) |
| Inhibits TNBS-induced colitis | (Sutton et al., 2008) |
| Inhibits Type I diabetes | (Liu et al., 2009; Saunders et al., 2006) |
| Allergy | |
| Inhibits airway allergic inflammation | (Kitagaki et al., 2006; Wilson et al., 2005) |
| Inhibits food allergy | (Bashir et al., 2002) |
| Co-infections | |
| Reduces liver immunopathological reactions to schistosome eggs | (Bazzone et al., 2008) |
| Exacerbates Plasmodium chabaudi and P. yoelii infections, suppressing IFN-γ responses | (Helmby, 2009; Noland et al., 2008; Su et al., 2005; Tetsutani et al., 2009) |
| Aggravates Citrobacter rodentium infection and colitis | (Chen et al., 2005; Weng et al., 2007) |
| Extends Nippostrongylus brasiliensis, Trichuris muris and Trichinella spiralis infections, suppresses IL-9 and mast cell response | (Behnke et al., 1978; Behnke et al., 1993; Colwell and Wescott, 1973; Dehlawi et al., 1987; Jenkins and Behnke, 1977) |
| Modulates Helicobacter pylori-induced inflammation | (Fox et al., 2000) |
| Results in greater Eimeria facliformis proliferation | (Rausch et al., 2010) |
| Inhibits protective CD8+ T cell responses to Toxoplasma gondii | (Khan et al., 2008) |
| Reduced antibody responses to haemagglutinin in influenza A infections | (Chowaniec et al., 1972) |
| Reduces response to malaria and Salmonella vaccination | (Druilhe et al., 2006; Su et al., 2006; Urban et al., 2007) |
References
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Last updated 04 November 2011