Maizels Lab Publications 2011-2014 (227-281)

Publications 2011 (227 - 242)

  1. Allen, J.E. and Maizels, R.M. (2011) Diversity and dialogue in immunity to helminths. Nature Reviews Immunology 11: 375-388 PDF
  2. Artis, D. and Maizels, R.M. (2011) Acquired Immunity to Helminths. In The Immune Response to Infection (Eds, Kaufmann, S.H.E., Rouse, B.T., and Sacks, D.L). ASM Press, pp 311-321 PDF
  3. Babayan, S.A, Allen, J.E., Bradley, J.E., Geuking, M., Graham, A.L., Grencis, R.K., Kaufman, J., McCoy, K.D., Paterson, S., Smith, K.G.C., Turnbaugh, P.J., Viney, M.E., Maizels, R.M. and Pedersen, A.B. (2011) Wild immunology: converging on the 'real world'. Annals of the New York Academy of Sciences 1236:17-29 PDF
  4. Bourke, C.D., Maizels, R.M. and Mutapi, F. (2011) Acquired immune heterogeneity and its sources in human helminth infection. Parasitology 138: 139-159.
  5. Hewitson, J.P., Filbey, K., Grainger, J.R., Dowle, A.A., Pearson, M., Murray, J., Harcus, Y. and Maizels, R.M. (2011) Heligmosomoides polygyrus elicits a dominant nonprotective antibody response directed at restricted glycan and peptide epitopes. Journal of Immunology 178:4764-4777
  6. Hewitson, J.P., Harcus, Y., Murray, J., van Aagtmaal, M., Filbey, K.J, Grainger, J.R., Bridgett, S., Blaxter, M.L., Ashton, P.D, Ashford, D.A., Curwen, R.S., Wilson, R.A., Dowle A.A.. and Maizels, R.M. (2011) Proteomic analysis of secretory products from the model gastrointestinal nematode Heligmosomoides polygyrus reveals dominance of Venom Allergen-Like (VAL) proteins Journal of Proteomics, 74:1573-1594.
  7. Maizels, R.M. and Allen, J.E. (2011) Forestalling obesity by eosinophils and helminths. Science 332 : 186-187
  8. Maizels, R.M., Hewitson, J.P. and Gause, W.C. (2011). Heligmosomoides polygyrus: one species still. Trends in Parasitology 27: 100-101
  9. Maizels, R.M.and Smith, K.A. (2011) Regulatory T cells in Infection. Advances in Immunology (Eds A. Rudensky and S. Sakaguchi) 112: 73-136
  10. Mutapi, F., Bourke, C., Harcus, Y., Midzi, N., Mduluza, T., Turner, C.M., Burchmore, R. and Maizels, R.M. (2011) Differential recognition patterns of Schistosoma haematobium adult worm antigens by the human antibodies IgA, IgE, IgG1 and IgG4. Parasite Immunology 33: 181-192
  11. Mutapi, F., Imai, N., Nausch, N., Bourke, C., Rujeni, N., Mitchell, K., Midzi, N., Woolhouse, M., Maizels, R.M., and Mduluza, T. (2011) Autoimmune reactivity is inversely related to intensity of schistosome infection. PLOS One 6 (5): e19149.
  12. Nausch, N., Midzi, N., Mduluza, T., Maizels, R.M. and Mutapi, F. (2011) Regulatory T cells in human Schistosoma haematobium infections. PLOS One 6: e16860
  13. Smith, K.A., Hochweller, K., Hämmerling, G., Boon, L., MacDonald, A.S, and Maizels, R.M. (2011) Chronic helminth infection promotes immune regulation in vivo through dominance of CD11cloCD103– dendritic cells. Journal of Immunology 186 7098-7109
  14. Smith, K.A. and Maizels, R.M. (2011) Defeating sepsis by misleading MyD88. Nature Immunology 12: 284-286
  15. Sutherland, T.E., Andersen, O.A., Betou, M., Eggleston, I.M., Maizels, R.M., van Aalten, D. & Allen, J.E. (2011) Analysing airway inflammation with chemical biology: functional dissection of acidic mammalian chitinase activity with a selective drug-like inhibitor. Chemistry and Biology 18 : 569-579
  16. van der Werf, N., Redpath, S.A., Phythian-Adams, A.T., Azuma, M., Allen, J.E., Maizels, R.M., MacDonald, A.S and Taylor, M.D (2011) Th2 response to helminth parasites can be therapeutically enhanced by, but are not dependent upon, GITR-GITRL co-stimulation in vivo. Journal of Immunology 187: 1411-1420

Publications 2012 (243 - 256)

  1. Artis, D. and Maizels, R.M. (2012) A multitasking defence Nature 484: 458-459.
  2. Herbst, T., Esser, J., Prati, M., Kulagin, M., Stettler, R., Zaiss, M., Hewitson, J.P., Merky, M, Verbeek, J.S., Bourquin, C., Camberis, M., Prout, M., Maizels, R.M., Le Gros, G. and Harris, N.L. (2012) Antibodies and IL-3 support helminth-induced basophil expansion. Proceedings of the National Academy of Sciences USA, 109 : 14954-14959
  3. Hoflehner, E., Hufnagl, K, Schabussova, I, Jasinska, J., Hoffmann-Sommergruber, K., Bohle, B., Maizels, R.M. and Wiedermann, U. (2012) Prevention of birch pollen-related food allergy by mucosal treatment with multi-allergen-chimers in mice PLOS One 7 : e39409
  4. McSorley, H.J. and Maizels, R.M. (2012) Helminth infections and host immune regulation. Clinical Microbiology Reviews 25: 585-608
  5. McSorley, H.J., O’Gorman, M.T., Blair, N., Sutherland, T.E., Filbey, K.J., and Maizels, R.M. (2012) Suppression of Type 2 immunity and allergic airway inflammation by secreted products of the helminth Heligmosomoides polygyrus. European Journal of Immunology 42: 2667-2682
  6. Maizels, R.M. and Hewitson, J.P. (2012) Immune recognition of parasite glycans. In Anticarbohydrate Antibodies – From Molecular Basis to Clinical Application’ (Kosma P. & Müller-Loennies, S., Eds). Springer. ISBN 978-3-7091-0869-7, pp 161-180
  7. Maizels, R.M., Hewitson, J.P. and Smith, K.A.. (2012) Susceptibility and immunity to helminth parasites. Current Opinion in Immunology 24: 459-466
  8. Maizels, R.M., Hewitson, J.P., Murray, J., Harcus, Y., Dayer, B., Filbey, K.J., Grainger, J.R., McSorley, H.J., Reynolds, L.A. and Smith, K.A. (2012) Immune modulation and modulators in Heligmosomoides polygyrus infection. Experimental Parasitology 132: 76-89.
  9. Parkinson, J., Wasmuth, J.D., Salinas, G., Bizarro, C.V, Sanford, C., Berriman, M., Ferreira, H.B., Zaha, A., Blaxter, M.L., Maizels, R.M. and Fernandez, C. (2012) A transcriptomic analysis of Echinococcus granulosus larval stages: implications for parasite biology and host adaptation. PLOS Neglected Tropical Diseases, 6 :e1897 (26pp)
  10. Reynolds, L.A., Filbey, K.A. and Maizels, R.M. (2012) Immunity to the model intestinal parasite Heligmosomoides polygyrus. Seminars in Immunopathology (Ed. M. Stadecker) 34:829-846 Open Access PDF
  11. Reynolds, L.A. and Maizels, R.M. (2012) In the absence of TGF-β signaling in T cells, fewer CD103+ regulatory T cells develop, but exuberant IFN-γ production renders mice more susceptible to helminth infection. Journal of Immunology 189: 1113-1117
  12. Smith, K.A., Harcus, Y., Garbi, N., Hämmerling, G., MacDonald. A.S. and Maizels, R.M. (2012) Innate type 2 immunity in helminth infection acts redundantly and autonomously following CD11c+ cell depletion. Infection and Immunity 80: 3481-3489
  13. Taylor, M.D., van der Werf, N. and Maizels, R.M. (2012) T cells in helminth infection - the regulators and the regulated. Trends in Immunology 33: 181-189
  14. Wammes, L.J., Hamid, F., Wiria, A.E., Wiboqo, H. Sartono, E., Maizels, R.M., Smits, H.H., Supali, T. and Yazdanbakhsh, M. (2012) Regulatory T cells in human lymphatic filariasis: stronger functional activity in microfilaremics. PLOS Neglected Tropical Diseases 6(5): e1655

Publications 2013 (257 - 265)

  1. Hewitson, J.P., Ivens, A.C., Harcus, Y., Filbey, K.J., McSorley, H.J., Murray, J., Bridgett, S., Ashford, D., Dowle, A.A. and Maizels, R.M. (2013) Secretion of protective antigens by tissue-stage nematode larvae revealed by proteomic analysis and vaccination-induced sterile immunity. PLOS Pathogens 9(8): e1003492 (15 pp).
  2. Jenkins, S.J., Rückerl, D., Thomas, G., Hewitson, J.P., Duncan, S., Brombacher, F., Maizels, R.M., Hume, D.A. and Allen J.E. (2013) IL-4 directly signals tissue resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1. Journal of Experimental Medicine 210: 2477-2491
  3. 259. McSorley, H.J., Hewitson, J.P. and Maizels, R.M. (2013) Immunomodulation by helminth parasites : defining mechanisms and mediators. International Journal of Parasitology 43: 301-310
  4. Maizels, R.M. (2013) Toxocara canis : molecular basis of immune recognition and evasion. Veterinary Parasitology 193: 365-374
  5. Maizels, R.M. and Nussey, D.H. (2013) Into the wild: digging at immunology’s evolutionary roots. Nature Immunology 14: 879-883
  6. Redpath, S.A., van der Werf, N., Cervera, A.M., MacDonald, A.S., Gray, D., Maizels, R.M. and Taylor, M.D. (2013) ICOS controls Foxp3+ regulatory T cell expansion, maintenance, and IL-10 production during helminth infection. European Journal of Immunology 43:705-715
  7. Schabussova, I., Ul-Haq, O., Hoflehner, H., Agkün, J., Wagner, A., Loupal, G., Joachim, A., Ruttkowski, B., Maizels, R.M. and Wiedermann, U. (2013) Oesophagostomum dentatum extract modulates T cell-dependent immune responses to bystander antigens and prevents the development of allergy in mice. PLOS One 8: e67544 (12pp)
  8. Smith, K.A. and Maizels, R.M. (2013) Nematodes and T regulatory cells. In "Parasitic Nematodes - Molecular Biology, Biochemistry and Immunology, 2nd Edition (Eds., Kennedy, M.W. and Harnett, W.) CABI Publishers ISBN 978 1 84593 759 1
  9. Vukcevic, M., Zorzato, F., Keck, S., Tsakiris, D.A., Keiser, J., Maizels, R.M. and Treves, S. (2013) Gain of function of the immune system caused by a ryanodine receptor 1 mutation. Journal of Cell Science 126: 3485-3492

Publications 2014 (266 - 281)

  1. Albers, A., Sartono, E., Wahyuni, S., Yazdanbakhsh, M., Maizels, R.M., Klarmann-Schulz, U., Pfarr, K. and Hoerauf, A. (2014) Real-time PCR detection of the HhaI tandem DNA repeat in pre- and post-patent B. malayi infections: a study in Indonesian transmigrants. Parasites and Vectors 7:146
  2. Buck, A., Coakley, G., Simbari, F., McSorley, H.J., Quintana, J., Le Bihan, T., Kumar, S., Abreu-Goodger, C., Lear, M., Harcus, Y., Ceroni, A., Babayan, S.A., Blaxter, M.L., Ivens, I. and Maizels, R.M. (2014) Exosomes secreted by nematode parasites transfer small RNAs to mammalian cells and modulate innate immunity. Nature Communications 5:5488 DOI: 10.1038/ncomms6488
  3. Filbey, K.J., Grainger, J.R., Smith, K.A., Boon, L., van Rooijen, N., Harcus, Y., Jenkins, S., Hewitson, J.P. and Maizels, R.M. (2014) Innate and adaptive type 2 immune cell responses in genetically controlled resistance to intestinal helminth infection. Immunology and Cell Biology 92: 436-448
  4. Hewitson, J.P. and Maizels, R.M. (2014) Vaccination against helminth parasite infections. Expert Review of Vaccines 13: 473-487
  5. Hewitson, J.P., Rückerl, D., Harcus, Y., Murray, J., Webb, L., Babayan, S., Allen, J.E., Kurniawan, A. and Maizels, R.M. (2014) The secreted triose phosphate isomerase of Brugia malayi is required to sustain microfilaria production in vivo. PLOS Pathogens 10(2): e1003930
  6. Johnston, C.J.C., McSorley, H.J., Anderton, S., Wigmore, S, and Maizels, R.M. (2014) Helminths and transplantation tolerance. Transplantation 97: 127-132
  7. Lee, S.J. and Maizels, R.M. (2014) Inflammatory bowel disease. Evolutionary Medicine and Public Health 1:95
  8. McSorley, H.J., Blair, N., Smith, K.A., McKenzie, A.N.J. and Maizels, R.M. (2014) Blockade of IL-33 release and suppression of type 2 innate lymphoid cell responses by helminth secreted products in airway allergy. Mucosal Immunology 7: 1068-1078
  9. Maizels, R.M. and Gause, W.C. (2014) Perspective :How helminths go viral. Science 345: 517-518
  10. Maizels, R.M., McSorley, H.J. and Smyth, D.J. (2014). Helminths in the hygiene hypothesis - sooner or later? Clin Exp Immunol. 177: 38-46
  11. Maizels, R.M. and Withers, D.R. (2014) MHC-II - a mutual support system for ILCs and T cells ? Immunity 41:174-176
  12. Reynolds, L.A., Harcus, Y., Smith, K.A., Webb, L.M., Hewitson, J.P., Ross, E.A., Brown, S., Uematsu, S., Akira, S., Gray, M., Gray, D., MacDonald, A.S., Cunningham, A. and Maizels, R.M. (2014) MyD88 signaling inhibits protective immunity to the gastrointestinal helminth parasite Heligmosomoides polygyrus. Journal of Immunology 193: 2984-2993
  13. Reynolds, L.A., Smith, K.A., Filbey, K.J., Harcus, Y., Hewitson, J.P., Yebra, M. and Maizels, R.M. (2014) Commensal-pathogen interactions in the intestinal tract: Lactobacilli promote infection with, and are promoted by, helminth parasites. Gut Microbes 5:10-9
  14. Smith, K.A., and Maizels, R.M. (2014) IL-6 controls susceptibility to helminth infection by impeding Th2 responsiveness and altering the Treg cell phenotype in vivo. European Journal of Immunology 44 : 150-161
  15. Sotillo, J., Sánchez-Flores, A., Cantacessi, C., Harcus, Y., Pickering, D. Bouchery, T., Camberis, M., Tang, S.-C., Giacomin, P., Mulvenna, J., Mitreva, M., Berriman, M., LeGros, G., Maizels, R.M., Loukas, A. (2014) Secreted proteomes of different developmental stages of the gastrointestinal nematode Nippostrongylus brasiliensis. Molecular & Cellular Proteomics 13: 2736-2751
  16. Sutherland, T.R., Logan, N., Rückerl, D., Humbles, A.A., Stockinger, B., Maizels, R.M. and Allen, J.E. (2014) Chitinase-like proteins promote IL-17-mediated neutrophilia in a trade-off between nematode killing and host damage. Nature Immunology 15: 1116-1125