C-type lectins show Ca-dependent binding of specific glycan determinants, expressed by many helminth species [1]. They are especially prominent in the ES of Toxocara canis infective larvae, with major secreted proteins TES-32 [2] and TES-70 [3]. Both have acquired additional domains of the ShK family.
Modelling of the C-Type Lectin domain of TES-32/CTL-1 shows close conservation of structure compared to mammalian mannose binding protein MBP-1 [2].
[1] Loukas, A. and Maizels, R.M. (2000). Helminth C-type lectins and host-parasite interactions. Parasitol Today 16(8): 333-339. doi: 10.1016/s0169-4758(00)01704-x. PDF.
[2] Loukas, A.C., Mullin, N.P., Tetteh, K.K.A., Moens, L. and Maizels, R.M. (1999). A novel C-type lectin secreted by a tissue-dwelling parasitic nematode. Current Biology 9: 825-828. PDF.
[3] Loukas, A.C., Doedens, A., Hintz, M. and Maizels, R.M. (2000). Identification of a new C-type lectin, TES-70, secreted by infective larvae of Toxocara canis , which binds to host ligands. Parasitology 121: 545-554. PDF