There is currently no recombinant antigen-based vaccine against any helminth parasite, human or veterinary. A vaccine made from extracts of the ruminant barber’s pole worm (Barbervax) has been on the market since 2014, and numerous experimental vaccines have been trialled as reviewed in the publications below.
See also the Abundant Larval Transcript page for a filarial nematode vaccine antigen.
Maizels Lab Publications
Maizels, R.M. (2021). Identifying novel candidates and configurations for human helminth vaccines. Expert Rev Vaccines: 1-5. PDF on Publisher’s Website.
Drurey, C., Coakley, G. and Maizels, R.M. (2020). Extracellular vesicles: new targets for vaccines against helminth parasites. Int J Parasitol 50: 623-633. PDF on Publisher’s Website.
Coakley, G., McCaskill, J.L., Borger, J.G., Simbari, F., Robertson, E., Millar, M., Harcus, Y., McSorley, H.J., Maizels, R.M. and Buck, A.H. (2017). Extracellular vesicles from a helminth parasite suppress macrophage activation and constitute an effective vaccine for protective immunity. Cell Rep 19(8): 1545-1557. PDF on Publisher’s Website.
Gregory, W.F., Atmadja, A.K., Allen, J.E. and Maizels, R.M. (2000). The abundant larval transcript-1 and -2 genes of Brugia malayi encode stage-specific candidate vaccine antigens for filariasis. Infect Immun 68(7): 4174-4179. PDF on Publisher’s Website.
Hewitson, J.P., Filbey, K.J., Esser-von Bieren, J., Camberis, M., Schwartz, C., Murray, J., Reynolds, L.A., Blair, N., Robertson, E., Harcus, Y., Boon, L., Huang, S.C., Yang, L., Tu, Y., Miller, M.J., Voehringer, D., Le Gros, G., Harris, N. and Maizels, R.M. (2015). Concerted activity of IgG1 antibodies and IL-4/IL-25-dependent effector cells trap helminth larvae in the tissues following vaccination with defined secreted antigens, providing sterile immunity to challenge infection. PLoS Pathog 11(3): e1004676. PDF on Publisher’s Website.
Hewitson, J.P. and Maizels, R.M. (2014). Vaccination against helminth parasite infections. Expert Rev Vaccines 13: 473-487. 10.1586/14760584.2014.893195. Download PDF.