Crystal structure of Brugia malayi MIF-2 (Zang et al., 2002)
Publications on MIF proteins from helminth parasites
Maizels Lab
Zang, X., Taylor, P., Wang, J.M., Meyer, D.J., Scott, A.L., Walkinshaw, M.D., and Maizels, R.M. (2002). Homologues of human macrophage migration inhibitory factor from a parasitic nematode. Gene cloning, protein activity, and crystal structure. J Biol Chem 277, 44261-44267.
Nisbet, A.J., Bell, N.E., McNeilly, T.N., Knox, D.P., Maizels, R.M., Meikle, L.I., Wildblood, L.A., and Matthews, J.B. (2010). A macrophage migration inhibitory factor-like tautomerase from Teladorsagia circumcincta (Nematoda: Strongylida). Parasite Immunol 32, 503-511.
Falcone, F.H., Loke, P., Zang, X., MacDonald, A.S., Maizels, R.M., and Allen, J.E. (2001). A Brugia malayi homolog of macrophage migration inhibitory factor reveals an important link between macrophages and eosinophil recruitment during nematode infection. J Immunol 167, 5348-5354.
Publications on the role of host MIF in helminth immunity
Filbey, K.J., Varyani, F., Harcus, Y., Hewitson, J.P., Smyth, D.J., McSorley, H.J., Ivens, A., Nylen, S., Rottenberg, M., Loser, S., and Maizels, R.M. (2019). Macrophage Migration Inhibitory Factor (MIF) Is Essential for Type 2 Effector Cell Immunity to an Intestinal Helminth Parasite. Front Immunol 10, 2375.
Varyani, F., Loser, S., Filbey, K.J., Harcus, Y., Drurey, C., Poveda, M.C., Rasid, O., White, M.P.J., Smyth, D.J., Gerbe, F., Jay, P. and Maizels, R.M. (2022). The IL-25-dependent tuft cell circuit driven by intestinal helminths requires macrophage migration inhibitory factor (MIF). Mucosal Immunol 15(6): 1243-1256. PMC9705247 10.1038/s41385-022-00496-w. https://www.ncbi.nlm.nih.gov/pubmed/35288645