Suppression of IBD in the laboratory model Heligmosomoides polygyrus
Model | Detail | Suppression | Reference |
IL-10-deficient colitis | C57BL/6 piroxicam-induced | Histopathology, IFN-γ and IL-12 | Elliott et al., 2004 |
T cell transfer | IL-10-/- T cells + piroxicam | Histopathology | Metwali et al., 2006 |
TNBS colitis | C57BL/6 d14 infection, d4 colitis | Histopathology | Setiawan et al., 2007 |
TNBS colitis | BALB/c d10 infection, d4 colitis | Histopathology, IFN-γ and TNF | Sutton et al., 2008 |
T cell transfer | IL-10-/- T cells + piroxicam | Histopathology, IFN-γ and IL-17 | Hang et al., 2010, 2013 |
OVA-specific colitis | OVA-specific T cells and oral OVA | Histopathology, IFN-γ and IL-17 | Leung et al., 2012 |
DSS colitis | BALB/c mice, up to 18 days | Weight loss and fecal blood | Donskow-Lysniewska 2013 |
Suppression of IBD by TGM1 from Heligmosomoides polygyrus
Smyth, D.J., Ren, B., White, M., McManus, C., Webster, H., Shek, V., Evans, C., Pandhal, J., Fields, F., Maizels, R.M. and Mayfield, S. (2021). Oral delivery of a functional algal-expressed TGF-β mimic halts colitis in a murine DSS model. Journal of Biotechnology 340 : 1-12. PDF on Publisher’s Website
Smyth, D.J., White, M.P.J., Johnston, C.J.C., Donachie, A.-M., Campillo Poveda, M, McSorley, H.J. and Maizels, R.M. (2023) Protection from T cell-dependent colitis by the helminth-derived immunomodulatory mimic of transforming growth factor-β, TGM. Discovery Immunology 2: 1-12. doi.org/10.1093/discim/kyad001
Maizels Lab Reviews
Maizels, R.M., McSorley, H.J. and Smyth, D.J. (2014). Helminths in the hygiene hypothesis – sooner or later ? Clin Exp Immunol 177: 38-46. 10.1111/cei.12353. PDF on Publisher’s Website