Cunningham, K.T., Ciancia, C., Campion, T., van Dinther, M., Davis, N. Duffy, A., Power, L., Sanders, A., Singh, S.P., Smyth, D.J., Thompson, E., White, R., Hinck, A.P., ten Dijke, P. and Maizels, R.M. (2026) Molecular engineering of the helminth TGFβ mimetics, TGM1 and TGM4 reveals a novel antagonist of TGF-β signaling in fibroblasts. FASEB Journal 40: e71338. https://doi.org/10.1096/fj.202503194R
New paper comparing the TGF-β mimics TGM1 and TGM4 reveal that the latter is a novel antagonist of signalling in fibroblasts, attributable to Domains 1and 2 which bind to TGF-β receptor I (TGFBR1). Open Access PDF.