We are excited to see our new paper, first authored by Shashi Singh, on how TGM4 has preference for myeloid cell activation through an extended set of co-receptors: download the PDF here ! Singh, S.P., Smyth, D.J., Cunningham, K.T., Mukundan, […]
Read moreOur collaboration with Philippe Jay at INSERM in Montpellier has continued with a new publication in Immunity, Tuft cell acetylcholine is released into the gut lumen to promote anti-helminth immunity, by Marième Ndjim et al – click here for link to […]
Read moreAugust 2023 : Exciting new data showing that TGM1 (H. polygyrus Transforming Growth factor-beta Mimic-1) binds not only the mammalian TGFβ receptors (as shown by Mukundan et al, 2022, doi 10.1016/j.jbc.2022.101994), but also CD44, enhancing potency for induction of regulatory T […]
Read moreRick Maizels’ commentary on the great paper By Shinoda et al (https://doi.org/10.1073/pnas.2108686119), is now published ! Open Access Commentary on PNAS website here. Maizels, R.M. (2022) Ascarosides from helminths pack a punch against allergy. Proc Natl Acad Sci USA 119: e2202250119.
Read moreFumi Varyani’s paper on the role of MIF in innate immunity to Nippostrongylus brasiliensis infection is now out in Mucosal Immunity! The IL-25-dependent tuft cell circuit driven by intestinal helminths requires macrophage migration inhibitory factor (MIF) –Open Access – click […]
Read moreDrurey, C., Lindholm, H., Coakley, G., Campillo Poveda, M., Loeser, S., Doolan, R., Gerbe, F., Jay, P., Harris, N., Oudhoff, M.J. and Maizels, R.M. (2022) Intestinal epithelial tuft cell induction is negated by a murine helminth and its secreted products.
Read more[mp_row] [mp_span col=”12″] A new comprehensive review on molecular mediators from helminths has been co-authored by Rick Maizels, Hermelijn Smits (Leiden University Medical Center) and Henry McSorley (University of Edinburgh). Maizels RM, Smits HH, & McSorley HJ (2018) Modulation of […]
Read moreSmith, K.A., Löser, S., Varyani, F., Harcus, Y., McSorley, H.J., McKenzie, A.N.J. and Maizels, R.M. (2018) Concerted IL-25R and IL-4Rα signaling drives innate type 2 effector immunity for optimal helminth expulsion. Open Access PDF
Read moreA short article on recent papers showing neuromedin U links the nervous and innate immune systems – Löser, S. and Maizels, R.M. (2018) Immunology: the nervous pathway to mucosal immunity. Current Biology 17: R33-R36 Download PDF
Read moreTwo Major New Papers out at the end of 2017 ! Johnston, C.J.C., Smyth, D.J., Kodali, R.B., White, M.P.J., Harcus, Y., Filbey, K.J., Hewitson, J.P., Hinck, C.S., Ivens, A., Kemter, A.M., Kildemoes, A.O., Le Bihan, T., Soares, D., Anderton, S.M., […]
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