Author: Rick Maizels

August 2023 : Exciting new data showing that TGM1 (H. polygyrus Transforming Growth factor-beta Mimic-1) binds not only the mammalian TGFβ receptors (as shown by Mukundan et al, 2022, doi 10.1016/j.jbc.2022.101994), but also CD44, enhancing potency for induction of regulatory T […]

Rick Maizels’ commentary on the great paper By Shinoda et al (https://doi.org/10.1073/pnas.2108686119), is now published ! Open Access Commentary on PNAS website here. Maizels, R.M. (2022) Ascarosides from helminths pack a punch against allergy. Proc Natl Acad Sci USA 119: e2202250119.

Fumi Varyani’s paper on the role of MIF in innate immunity to Nippostrongylus brasiliensis infection is now out in Mucosal Immunity! The IL-25-dependent tuft cell circuit driven by intestinal helminths requires macrophage migration inhibitory factor (MIF) –Open Access – click […]

Drurey, C., Lindholm, H., Coakley, G., Campillo Poveda, M., Loeser, S., Doolan, R., Gerbe, F., Jay, P., Harris, N., Oudhoff, M.J. and Maizels, R.M.  (2022) Intestinal epithelial tuft cell induction is negated by a murine helminth and its secreted products.

[mp_row] [mp_span col=”12″] A new comprehensive review on molecular mediators from helminths has been co-authored by Rick Maizels, Hermelijn Smits (Leiden University Medical Center) and Henry McSorley (University of Edinburgh). Maizels RM, Smits HH, & McSorley HJ (2018) Modulation of […]

Smith, K.A., Löser, S., Varyani, F., Harcus, Y., McSorley, H.J., McKenzie, A.N.J. and Maizels, R.M. (2018) Concerted IL-25R and IL-4Rα signaling drives innate type 2 effector immunity for optimal helminth expulsion. Open Access PDF  

A short article on recent papers showing neuromedin U links the nervous and innate immune systems – Löser, S. and Maizels, R.M. (2018) Immunology: the nervous pathway to mucosal immunity. Current Biology 17: R33-R36 Download PDF